Scooby-Doo

Freddie Prinze Jr.

As Fred

Sarah Michelle Gellar

As Daphne

Matthew Lillard

As Shaggy

Linda Cardellini

As Velma

Neil Fanning

As Scooby Voice (voice)

Rowan Atkinson

As Mondavarious

Isla Fisher

As Mary Jane

Miguel A. Núñez Jr.

As Voodoo Maestro

Steven Grives

As N' Goo Tuana

Charles Stan Frazier

As Sugar Ray

Craig Bullock

As Sugar Ray

Matthew Murphy Karges

As Sugar Ray

Mark McGrath

As Sugar Ray

Rodney Sheppard

As Sugar Ray

Sam Greco

As Zarkos

Charlie Cousins

As Velma's Friend

Kristian Schmid

As Brad

Nicholas Hope

As Old Man Smithers

Scott Innes

As Scrappy Voice (voice)

J.P. Manoux

As Scrappy Rex Voice (voice)

Chris Cruickshanks

As Tiny Henchman

Alex Ruiz

As Reporter #1

Sheryl Benko

As Reporter #2

Rio Nugara

As Island Emissary

David Vallon

As Bartender Dead Mike's

Troy MacKinder

As Guy in the Vat

Michala Banas

As Carol

Holly Brisley

As Training Video Woman

Robert Díaz

As Training Video Guy #1

Remi Broadway

As Training Video Guy #2

Martin Broome

As Melvin Doo

Simone Dumbleton

As Co-Ed

Jonathan Coffey

As Fitzgibbon

Michael Caffery

As Coast Guard #2

Kyas Sherriff

As Airport Attendant

Celeste Gosnell

As Airport Family

Bradley Gosnell

As Airport Family

Cayley Gosnell

As Airport Family

Audrey Gosnell

As Airport Family

Kurt Duval

As Spooky Hotel Bartender

Janis McGavin

As Co-Ed Hottie

Emily Gosnell

As Autograph Seeker

Marea Lambert Barker

As Autograph Seeker

Kym Jackson

As Autograph Seeker

Danielle Starkey

As Autograph Seeker

Andrew Bryniarski

As Cavern Henchman

Craig Behenna

As Henchman #1

Keith S. Bullock

As Henchman #2

Jess Harnell

As Creature Voices (voice)

Frank Welker

As Creature Voices (voice)

Pamela Anderson

As Pamela Anderson (uncredited)