Slither

Nathan Fillion

As Bill Pardy

Michael Rooker

As Grant Grant

Elizabeth Banks

As Starla Grant

Gregg Henry

As Jack MacReady

Tania Saulnier

As Kylie Strutemyer

Don Thompson

As Wally

Brenda James

As Brenda Gutierrez

Jennifer Copping

As Margaret

Jenna Fischer

As Shelby

Haig Sutherland

As Trevor

William MacDonald

As Mr. Strutemyer

Iris Quinn

As Mrs. Strutemyer

Matreya Fedor

As Emily Strutemyer

Amber Lee Bartlett

As Jenna Strutemyer

Xantha Radley

As Uptight Mom

Dustin Milligan

As Drawing Boy

Lloyd Kaufman

As Sad Drunk

Zak Ludwig

As Gina Kid

Tom Heaton

As Tourneur

Mary Black

As Woman in Basement

Ben Cotton

As Charlie

Lorena Gale

As Janene

Dee Jay Jackson

As Dwight

Nicholas Podbrey

As Diseased Grant part 1

Malcolm Scott

As Dude Joining Grant

Darren Shahlavi

As Brenda's Husband

Kathryn Kirkpatrick

As Karaoke Woman

Corb Lund

As Lead Singer

Michael Cromien

As Fitzgibbon

Robert Musnicki

As Diseased Leader

Stephen Park

As Gleeked on Guy

Nicholas Podbrey

As Diseased Grant #1

Jeny Cassady

As Diseased Grant #2

Alette Falle

As Diseased Grant #3

Matt McInnis

As Head-Shot Norman

James Gunn

As Hank (uncredited)

Magda Apanowicz

As Friend (uncredited)

Rick Morwick

As Truck Driver (uncredited)

Rob Zombie

As Dr. Karl (voice)

Mark Torgl

As Melvin Junko (Archive footage)