Spider-Man

Tobey Maguire

As Spider-Man / Peter Parker

Willem Dafoe

As Green Goblin / Norman Osborn

Kirsten Dunst

As Mary Jane Watson

James Franco

As Harry Osborn

Cliff Robertson

As Ben Parker

Rosemary Harris

As May Parker

J.K. Simmons

As J. Jonah Jameson

Joe Manganiello

As Flash Thompson

Gerry Becker

As Maximilian Fargas

Bill Nunn

As Joseph 'Robbie' Robertson

Jack Betts

As Henry Balkan

Stanley Anderson

As General Slocum

Ron Perkins

As Dr. Mendel Stromm

Michael Papajohn

As Carjacker

K.K. Dodds

As Simkins

Ted Raimi

As Hoffman

Bruce Campbell

As Ring Announcer

Elizabeth Banks

As Miss Brant

John Paxton

As Houseman

Tim DeZarn

As Philip Watson

Taylor Gilbert

As Madeline Watson

Randy Poffo

As Bone Saw McGraw

Larry Joshua

As Wrestling Promoter

Timothy Patrick Quill

As Wrestling Arena Guard

Lisa Danielle

As Bone-ette

Natalie T. Yeo

As Bone-ette

Erica D. Porter

As Bone-ette

Kristen Davidson

As Bone-ette

Jason Padgett

As Flash's Crony

Shan Omar Huey

As Teacher

Sally Levi

As Girl on Bus

Evan Arnold

As Doctor

Jill Sayre

As Nurse

Jim Ward

As Project Coordinator

David Holcomb

As Test Pilot

Octavia Spencer

As Check-In Girl

Brad Grunberg

As Heckler

Shane Habberstad

As Little Billy

Deborah Wakeham

As Billy's Mom

Rachael Bruce

As Times Square Child

Mackenzie Bryce

As Times Square Child

Julia Barrie

As Times Square Child

Macy Gray

As Macy Gray

Myk Watford

As Cop at Fire

Bill Calvert

As Fireman

Sylva Kelegian

As Mother at Fire

Kristen Marie Holly

As Young Lady at Fire

Ajay Mehta

As Cabbie

Peter Appel

As Cabbie

Scott Spiegel

As Marine Cop

Matt Smith

As Cop at Carjacking

Sara Ramirez

As Cop at Carjacking

Lucy Lawless

As Punk Rock Girl

Jayce Bartok

As Subway Guitarist

Maribel González

As Lady Dogwalker

Amy Bouril

As Office Lady

Joseph D'Onofrio

As Opinionated Cop

Jim Norton

As Surly Truck Driver

Corey Mendell Parker

As Chaperone in Tram

Ashley Edner

As Girl in Tram

William Joseph Firth

As Boy in Tram

Alex Black

As Boy in Tram

Laura Gray

As Tram Group Mother

Joe Virzi

As New Yorker on Bridge

Michael Edward Thomas

As New Yorker on Bridge

Jeanie Fox

As New Yorker on Bridge

Robert Kerman

As Tugboat Captain

Stan Lee

As Man in Fair (uncredited)

Una Damon

As Lab Tour Guide (uncredited)

Rick Avery

As Cop (uncredited)

Peter Aylward

As Colonel (uncredited)

Jillian Clare

As Crying Girl in Tram (uncredited)

Chris Coppola

As Kyle (uncredited)

Jesse Heiman

As Spectator at School Fight (uncredited)

Leroy Patterson

As World Unity Festival Attendant (uncredited)

Benny Urquidez

As Mugger (uncredited)

Scott L. Schwartz

As Screaming Wrestler (uncredited)

Jophery C. Brown

As Chef (uncredited)

Brian J. Williams

As Young Thug #2 (uncredited)

Mark De Alessandro

As Cop (uncredited)

Tia Dionne Hodge

As Uptown Woman (uncredited)

Loren Janes

As Board of Directors Member (uncredited)

Andray Johnson

As Balkan's Aide (uncredited)

Martin Pfefferkorn

As Thug on 8x10 (uncredited)

Tammi Sutton

As Street Vendor (uncredited)

Lindsay Thompson

As Mary Jane's Friend (uncredited)

Sean Valla

As Boat Light Man (uncredited)

Pete Macnamara

As Pentagon Officer (uncredited)

Al Goto

As Cop (uncredited)

Joni Avery

As Cop (uncredited)

Sam Raimi

As Popcorn Thrower (uncredited)

Craig 'Radio Man' Castaldo

As Man with Bike (uncredited)

Lou Torres

As Enrique