Uncle Drew

Kyrie Irving

As Uncle Drew

Lil Rel Howery

As Dax Winslow

Shaquille O'Neal

As Big Fella

Chris Webber

As Preacher

Reggie Miller

As Lights

Nate Robinson

As Boots

Lisa Leslie

As Betty Lou

Erica Ash

As Maya

Tiffany Haddish

As Jess

Nick Kroll

As Mookie Bass

Aaron Gordon

As Casper Jones

Mike Epps

As Louis

JB Smoove

As Angelo

Wesley Witherspoon

As Mario

Thomas Mills

As Duke Tango

Selema Masekela

As Sal Masekela

Adam Lazarre-White

As Frankie the Tournament Director / Narrator

Lavar Walker

As Marty the Manager

John Calipari

As John Calipari

Joe Hammond

As Joe Hammond

Scoop Jackson

As Scoop Jackson

Pee Wee Kirkland

As Pee Wee Kirkland

Earl Monroe

As Earl Monroe

Chris Mullin

As Chris Mullin

Maurice G. Smith

As Dominic 'The Glove' Willis

Kevin Benton

As Zeke 'The Mouth' Murray

Bill Walton

As Bill Walton

George Gervin

As George Gervin

Steve Nash

As Steve Nash

David Robinson

As David Robinson

Jerry West

As Jerry West

Rick Barry

As Rick Barry

Dikembe Mutombo

As Dikembe Mutombo

NeNe Leakes

As Nene Leakes

Aiden Williams

As Adopted Kid

Tinuke Adetunji

As Angelo's Girl

Deadra Moore

As Desk Nurse

Enoch King

As Baby's Dad

Crystal Lee Brown

As Mom

Kenneth Crudup

As Baller

Mark Robert Ellis

As Basketball Coach (as Mark Ellis)

Terence Rosemore

As Customer #1

Terrence 'T.C.' Carson

As Customer #2

Rick Ross

As Customer #3

Trey Griffith

As Dax - 4 Years Old

Judah Howery

As Dax - 10 Years Old

Ashton Tyler

As Young Dax

Carrie Walrond Hood

As Foot Locker Mother

Lorenzo Davis

As Opponent

Brian Kortovich

As Opponent

Keith Jamal Evans

As Other Kid (as Keith Evans)

Josh Henry

As Paramedic

Phil Ductan

As Player

Elijah Everett

As Player

Rocco Poveromo

As Referee

Barry Rohrssen

As Referee

Scott Van Pelt

As Scott Van Pelt - ESPN Host (uncredited)

Jamel Chambers

As Angry Fan

Alannah Wilhite

As Girl in club

Matt McHugh

As Security Guard

Dario A. Lee

As The Destroyer (uncredited)