Super

Rainn Wilson

As Frank Darbo

Elliot Page

As Libby

Liv Tyler

As Sarah

Kevin Bacon

As Jacques

Gregg Henry

As Detective John Felkner

Michael Rooker

As Abe

Andre Royo

As Hamilton

Sean Gunn

As Toby

Stephen Blackehart

As Quill

Linda Cardellini

As Pet Store Employee

Nathan Fillion

As The Holy Avenger

Don Mac

As Mr. Range

Gerardo Davila

As Cop

Grant Goodman

As Young Frank

Paul T. Taylor

As Frank Sr.

Connor Day

As Teenage Frank

James Gunn

As Demonswill

Mikaela Hoover

As Holly

Nick Holmes

As Jim

Matt Moore

As Jesus / Guy In Line

Rob Zombie

As Voice Of God (voice)

Steve Agee

As Comic Book Store Jerk

Laurel Whitsett

As Librarian

James Lentzsch

As Passenger Teen

Nate Rubin

As Driving Teen

Edrick Browne

As Nathaniel

Danny Cosmo

As Purse-snatcher

Krystal Mayo

As Wheelchair Woman

Russell Towery

As Chickenhawk

Mario Jiminez Jr.

As Chicken

Jonathan Winkler

As Transvestite

Mollie Milligan

As Sarah's Sister

Gerry May

As Newscaster

Valentine Miele

As Line Butter

Michelle Gunn

As Line Butter's Girlfriend

Darcel White Moreno

As Waitress

Greg Ingram

As Long-haired Hood

Lindsay Soileau

As Libby's Friend

Brandon Belknap

As Christian

Zach Gilford

As Jerry

Lloyd Kaufman

As 911 Man

Tim J. Smith

As Range's Technician

Mark De Alessandro

As Thug Jumped On By Boltie

Cole S. McKay

As Thug Set On Fire

Dominick LaBanca

As Thug #1

John W. Lawson

As Thug Missing Arms

William Katt

As Sgt. Fitzgibbon

Christine Quinn

As Stoner Girl