Big Trouble

Tim Allen

As Eliot Arnold

Rene Russo

As Anna Herk

Ben Foster

As Matt Arnold

Jason Lee

As Puggy

Stanley Tucci

As Arthur Herk

Dennis Farina

As Henry Desalvo

Zooey Deschanel

As Jenny Herk

Janeane Garofalo

As Monica Romero

Sofía Vergara

As Nina

Tom Sizemore

As Snake

Johnny Knoxville

As Eddie

Omar Epps

As Seitz

Heavy D

As Greer

Patrick Warburton

As Walter Kramitz

Jack Kehler

As Leonard

DJ Qualls

As Andrew

Michael McShane

As Bruce

Andy Richter

As Jack/Ralph Pendick

Daniel London

As John

Lars Arentz-Hansen

As Leo

Cullen Douglas

As Captain Justin Hobart

Flip Schultz

As Co-Pilot Jan Vigushin

Patrick Mickler

As Cigar Buddy

Gerald Owens

As Cigar Buddy

Mitchell Carrey

As Cigar Buddy

Nathalie Latronico

As Heather Weintraub

Jon Kasdan

As Jack Pendick Trainee

Ian Marioles

As Editorial Assistant

Philip Nolen

As Deeber

David Koepp

As Annoyed Sports Radio Host (voice)

Barry Sonnenfeld

As Confused Sports Radio Call In (voice)

Jay Rasumny

As Courier #1

Ruben Gomez

As Courier #2

Antoni Corone

As William Spaulding

Siobhan Fallon Hogan

As Fly by Air Ticket Agent

Kava Stewartson

As Sour Airport Security

Gloria Laino

As Airport X-Ray Operator

Carmen López

As Airport Stern Security Woman

Mark Salem

As Fly By Air Baggage Handler

Renato Campilongo

As Gang Leader

Marc Macaulay

As Arch Ridley

James Martin Kelly

As Geo Salesman

Dave Corey

As Cellmate Dwight

Selma Cipes

As Retiree #1

Sid Raymond

As Retiree #2

Jody Wilson

As Retiree #3

Maurice Alvey

As Retiree #4

Mia Finnegan

As Aerobics Announcer (voice)

Eric Geller

As Aerobics Announcer (voice)

Paul Barth

As Airline Pilot

Martha Stewart

As Herself

Deborah Smith Ford

As Bag Lady (uncredited)

Ron Madoff

As Extra