Osmosis Jones

Chris Rock

As Osmosis Jones (voice)

Laurence Fishburne

As Thrax (voice)

David Hyde Pierce

As Drix (voice)

Brandy Norwood

As Leah (voice)

Elena Franklin

As Shane Detorre

Bill Murray

As Frank Detorre

William Shatner

As Mayor Phlegmming (voice)

Ron Howard

As Tom Colonic (voice)

Kid Rock

As Kidney Rock (voice)

Molly Shannon

As Mrs. Boyd

Chris Elliott

As Bob

Jonathan Adams

As Officer Tom (voice)

Carlos Alazraqui

As Spanish Germ (voice)

Keith Anthony

As Additional Character Voices (voice)

Eddie Barth

As Conductor (voice)

Sally Brooks

As Additional Character Voices (voice)

Rodger Bumpass

As Joe Cramp / Announcer for Nerve News Network (voice)

Michael Carven

As Additional Character Voices (voice)

Paul Christie

As Dan Matter / Germ (voice)

Janis Dardaris

As Additional Character Voices (voice)

Wendy Dillon

As Additional Character Voices (voice)

Antonio Fargas

As Chill the Flu Shot (voice)

Eddie Frierson

As Frank Police Department Officer (voice)

Donald Fullilove

As Doughnut (voice)

Jackie Gonneau

As Additional Character Voices (voice)

Shannon Gregory

As Additional Character Voices (voice)

Richard Steven Horvitz

As Additional Character Voices (voice)

Rif Hutton

As Charlie (voice)

Art Kimbro

As Additional Character Voices (voice)

Joyce Kurtz

As Additional Character Voices (voice)

Anne Lockhart

As Female Red Blood Cell (voice)

Sherry Lynn

As Trudy (voice)

Danny Mann

As Musician Cell (voice)

Mickie McGowan

As Brain Librarian (voice)

Kenny Olson

As Kidney Rock Band (voice)

Jason Krause

As Kidney Rock Band (voice)

Joe C.

As Kidney Rock Band (voice)

Stefanie Eulinberg

As Kidney Rock Band (voice)

Jimmie Bones

As Kidney Rock Band (voice)

Uncle Kracker

As Kidney Rock Band (voice)

Joel Silver

As Police Chief (voice) (uncredited)

David Ossman

As Scabies (voice) (uncredited)

John Melendez

As Artie (voice)

Héctor Mercado

As Additional Character Voices (voice)

Paul Pape

As Male Red Blood Cell #2 (voice)

Marilyn Pasekoff

As Additional Character Voices (voice)

Chris Phillips

As Firefighter Doug (voice)

Lynne Redding

As Additional Character Voices (voice)

Al Rodrigo

As Frank Police Department Walkie Talkie (voice)

Herschel Sparber

As Bruiser (voice)

Doug Stone

As Police Officer Jamie (voice)

Steve Susskind

As Mob Boss Germ (voice)

Keri Tombazian

As Additional Character Voices (voice)

Paul Tuerpe

As Additional Character Voices (voice)

Robert Wisdom

As Big Germ (voice)

Danny Murphy

As Zookeeper Superintendent

Jack McCullough

As Zookeeper

Will Dunn

As Oyster Boy

Jackie Flynn

As School Janitor

Kelsey Jordan

As Bus Girl #1

Abe Farrelly

As Bus Girl #2

Jesse Peter

As Laughing Boy

John-Eliot Jordan

As Pea Soup Manager

Nancy Byers

As Pea Soup Supervisor

Kevin J. Flynn

As Docky's Clamshack Waiter

Sean Gildea

As Dreamy Photographer

Kathryn Frick

As Nurse #1

Nikki Tyler-Flynn

As Nurse #2

Elizabeth Jordan

As Nurse #3

Zen Gesner

As ER Doctor #1

Marc Hyman

As ER Doctor #2

Zak Penn

As ER Doctor #3

Diane Conrad

As Zoo Visitor or Staff

Judith Conrad

As Zoo Visitor or Staff

Thomas Jordan

As The Zoo Visitor or Staff

Sydney J. Bartholomew Jr.

As Zoo Visitor or Staff

Erica Johnson

As Zoo Visitor or Staff

Bo Cleary

As Pea Soup Staff

Bruce McIntyre

As Pea Soup Staff

Colleen O'Donnell

As Docky's Clamshack

Docky

As The Bikini Gang

Joe Murphy

As The Bikini Gang

Brian Mone

As Police Officer

Sean Fitzgerald

As Police Officer

Grace Costa

As ER Nurse

Emily O’Donnell

As School Girl